Synthesis of Zinc(II)-natural zeolite mordenite type as a drug carrier for ibuprofen: Drug release kinetic modeling and cytotoxicity study

Zn(II)-ZMT material development based on natural zeolite mordenite type (ZMT) as a drug carrier for ibuprofen has been explored and assessed. The ion exchange method was carried out to prepare material. XRD, FTIR, FESEM-EDS were used characterize the physico-chemical characteristics of all materials. performance delivery agent also evaluated using loading-release, zeta potential measurement, cytotoxicity testing. Six kinetic models (including zero-order, first-order, Peppas-Sahlin, Higuchi, Hixson-Crowell, Korsmeyer-Peppas models) utilized simulate release process. Meanwhile, microtetrazolium (MTT) assay analyze material's cytotoxicity. loading content (DLC) 90.37% an efficiency entrapment (EEC) 54.22%, according loading. releases modeling Ibuprofen from followed Hixson-Crowell model. This exhibits good biocompatibility test MTT assay. [email protected](II)-ZMT - 61.55 mV ± 0.1 mV. These findings suggest that in dispersion system high degree stability, indicating it will not flocculate or coagulate body. Furthermore, is inorganic substance be employed medication future.